Kennedy dynasty touched repeatedly by tragedy

The Kennedy dynasty has been touched repeatedly by tragedy — most recently the death of Robert F. Kennedy’s granddaughter Saoirse Kennedy Hill at age 22.
Some notable other instances:
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JOSEPH P. KENNEDY JR.: Died in a plane crash during World War II. He was 29.
ROSEMARY KENNEDY: Had been institutionalized since 1941 because she was mentally disabled and due to the effects of a failed lobotomy. She died in 2005.
KATHLEEN KENNEDY: Married William John Robert Cavendish, the Marquess