Steroids may up effectiveness of AAV-based gene therapy

Washington D.C. [USA], Jun 11 : Glucocorticoid steroids, such as prednisone, may improve effectiveness of AAV-based gene therapy by reducing immune response, according to a recent research. The study of gene transfer using adeno-associated virus -based gene delivery into skeletal muscle of rhesus macaques showed that oral prednisone reduced immune responses to AAV that can weaken expression of the therapeutic transgene over time.