Five things you need to know today, and a big awards night

Good morning, Boston. Day Two of Teacher Appreciation Week. If you didn’t tell a teacher you appreciate them yesterday, today’s your day.
Here are the five things you need to know in Boston business news to start your workday.The largest life sciences employer in Mass. has notified state officials it plans to lay off up to 186 employees, including part of its gene therapies team, starting this summer, Rowan Walrath reports.Toast Inc. is planning to end its lease in one of Fenway's la