What Are the Prospects for Combating MDR Enterobacterales?

By Gina ShawAshlan Kunz Coyne, PharmDThe global rise of multidrug-resistant Enterobacterales—particularly those producing extended-spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) such as New Delhi metallo-beta-lactamase (NDM)—represents a growing clinical challenge with limited therapeutic options, according to experts at MAD-ID 2025, in Orlando, Florida.What are the prospects for new and pipeline antimicrobials to address these challenges?Rising community transmi