Filling the IV Daptomycin Dosing Knowledge Gap

By Marcus A. BanksIntravenous daptomycin is a valuable alternative to vancomycin when treating methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections and endocarditis, given its reduced risk for nephrotoxicity and infusion reactions.The Clinical and Laboratory Standards Institute recommends indication-specific dosing for daptomycin that includes 8 to 10 mg/kg for MRSA infections and 10 to 12 mg/kg for endocarditis or vancomycin-resistant enterococci (VRE) bacteremia (Clin Infe