Debating the Merits of Ceftriaxone Versus Cefazolin for MSSA Therapy

By Karen BlumHunter Rondeau, PharmDWhether ceftriaxone or cefazolin is preferred in the management of methicillin-susceptible Staphylococcus aureus (MSSA) was the subject of a good-natured, lively debate at the ASHP Midyear 2025 Clinical Meeting & Exhibition, in Las Vegas.MSSA is more common than its more resistant counterpart, methicillin-resistant S. aureus (MRSA), said Hunter Rondeau, PharmD, BCIDP, AAHIVP, an antimicrobial stewardship coordinator at SSM Health in St. Louis. Risk factors