Cefepime-Induced Neurotoxicity Can Occur Even With Guideline-Directed Dosing

More than half of patients received potentially neurotoxic doses of cefepime, according to a new retrospective analysis. Even guideline-directed dosing resulted in excessive cefepime trough levels.“Ninety-six percent of these patients did achieve target attainment. This suggests a low risk of treatment failure,” said presenting author Jillian Lachapelle, PharmD, a PGY-2 critical care pharmacy resident at MaineHealth Maine Medical Center, in Portland. The concern is not cefepime's the