Antibiotic Prophylaxis in Cirrhosis: What Is the Optimal Duration?

By Susan KreimerInternational guidelines recommending five to seven days of routine antibiotic prophylaxis in patients with cirrhosis and upper gastrointestinal bleeding warrant reassessment because they do not uphold the intended mortality benefit, according to a recent systematic review.Despite a reported decrease in infections with prophylaxis, concerns over inconsistent diagnostic criteria for infection and the potential for bias led investigators at McGill University Health Center, in Montr