Membrane-targeted DNA frameworks with biodegradability recover cellular function and morphology from frozen cells

DNA frameworks, nanostructures engineered from DNA, preserve cells by anchoring to membranes, inhibiting cellular ice growth, and degrading autonomously after thawing. These biodegradable cryoprotectants outperform conventional agents, improve recovery and function of frozen macrophage cells, and offer a promising strategy for biopreservation in research and therapeutic applications.