What's the right question to ask about GMOs?

I would argue that the source of a transgene and its method of introduction are irrelevant to the safety of the resulting plant. A gene is a gene — it is a sequence of DNA and, as a molecule, DNA has zero chance of harming you. The DNA can be from any organism — literally, any organism — and it is still just a sequence of the same chemical letters, A, T, G, and C. Moreover, the method of transgene introduction, be it by plant breeding or by t