The PLOS Comp Biol Macromolecular Structure and Dynamics collection

Living systems are in a state of perpetual motion. Down at the microscopic level, the atoms that make up biological macromolecules are, in the words of Richard Feynman, jiggling and wiggling. These atomic motions are beautifully choreographed and harnessed into productive events in the cell. Fluctuations of macromolecules between three-dimensional structures underlie all processes that maintain and replicate a living cell. Investigation of macromolecular structure and dynamics is fundamental to