New technique paves the way for drug targeting to fight microbial resistance

Research investigators in Singapore have developed a new high throughput method that identifies how ribonucleic acid (RNA) molecules come together in an unbiased and large-scale manner inside cells. Named SPLASH, or Sequencing of Psoralen Linked And Selected Hybrids, this newly-developed technique was used to describe the RNA network in human and yeast cells, its dynamics, and how the structural organisation impacts translation and decay processes in the cell.