Light switchable proteins and superresolution reveal moving protein complexes

Cells are restless. They move during embryogenesis, tissue repair, regeneration, chemotaxis. Even in disease, tumor metastasis, cells get around. To do this, they have to keep reorganizing their cytoskeleton, removing pieces from one end of a microtubule and adding them to the front, like a railroad with a limited supply of tracks. The EB family of proteins helps regulate this process and can act as a scaffold for other proteins involved in pushing the microtubule chain forward.