Label-free, real-time plasmonic sensing allows quantification of alternatively spliced mRNA isoforms

Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. It is a complex process that allows the generation of protein variants from a limited repertoire of protein-coding genes in eukaryotic organisms. Its deregulation is strongly linked to disease onset and progression. A recent paper in Biosensors and Bioelectronics reports a simple and robust technology using a surface plasmon resona