Bad timing is depressing: Disrupting the brain's internal clock causes depressive-like behavior in mice

Disruptions of daily rhythms of the body's master internal clock cause depression- and anxiety-like behaviors in mice, reports a new study. The findings provide insight into the role of the brain's internal time keeping system in the development of mood disorders, such as bipolar disorder and major depressive disorder, which have been associated with disturbed daily (circadian) rhythms.