Overcoming marketing roadblocks in regulated industries

How do you advertise in heavily regulated sectors? Of course self-regulation and co-regulation exists in the shape of the Advertising Standards Authority Certain sectors, however, such as the tobacco and alcohol industries, various aspects of financial services, gambling, online dating, healthcare, charities and transport are obligated to follow stricter rules and regulations. 
What, then, are the key strategies brands in these sectors should employ to ensure they stay both ahead of th