Adderall maker Shire agrees £46bn takeover by Takeda

Japanese drugmaker increases offer to secure biggest deal since 2000 in pharmaceutical sectorShire, the London-listed maker of treatments for ADHD and rare diseases, has finally agreed to a takeover by the Japanese firm Takeda after it raised its offer to £46bn, making it the biggest deal in the pharmaceutical sector since 2000.After being rebuffed four times, Takeda secured a recommendation from the Shire board by raising the amount of cash in its offer to $30.33 (£22.43) a share. S