The genetics of PKM{zeta} and memory maintenance

Elucidating the molecular mechanisms that maintain long-term memory is a fundamental goal of neuroscience. Accumulating evidence suggests that persistent signaling by the atypical protein kinase C (PKC) isoform protein kinase M (PKM) might maintain synaptic long-term potentiation (LTP) and long-term memory. However, the role of PKM has been challenged by genetic data from PKM-knockout mice showing intact LTP and long-term memory. Moreover, the PKM inhibitor peptideinhibitory peptide (ZIP) revers