[Perspective] Warburg meets epigenetics

We are all taught in biochemistry class that in the presence of oxygen, cells will use the tricarboxylic acid (TCA) cycle to efficiently generate adenosine 5′-triphosphate (ATP) via oxidative phosphorylation (OXPHOS). However, in 1924, the biochemist Otto Warburg observed that cancer cells do not follow this rule (1, 2). In fact, even in the presence of oxygen, cancer cells will depend on glycolysis (so-called aerobic glycolysis) to inefficiently generate ATP from glucose. More recently, there