Papers of note in Science 358 (6364)

This week’s articles highlight a newly identified component of methionine sensing; a mechanism by which nutrient depletion prevents the efflux of essential amino acids from lysosomes; how reactive oxygen species promote genome stability during metabolic stress; co-option of the cell cycle regulatory machinery to time the differentiation of multiciliated cells; and connections between olfaction, organismal metabolism, and longevity.