Molecular trigger for Cerebral Cavernous Malformation identified

(EMBO) Researchers in Italy, Germany and the United States have identified a regulatory protein crucial for the development of Cerebral Cavernous Malformation -- a severe and incurable disease mainly affecting the brain microvasculature. The results, which are published in EMBO Molecular Medicine, show that the KLF4 protein plays a central role in the development of CCM lesions.