Disrupting mitochondrial function could improve treatment of fungal infections

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50 percent and cause an estimated 1.5 million deaths worldwide annually. Current antifungal therapies are hampered by the increasingly frequent emergence