Using Oncolytic Viruses to Boost Response to Immune Checkpoint Inhibitors

Two unrelated research papers in Science Translational Medicine report how treatment with oncolytic viruses (OVs) can switch on the body’s immune system against different forms of cancer, and render traditionally hard-to-treat tumors susceptible to checkpoint inhibitor therapy.In one of the reported studies, scientists at the University of Leeds in the U.K. describe positive data from an early clinical trial in nine patients with either glioma or brain metastases, who were given intravenou