Tumors Shrink, or Grow, Depending on Drug Receptor–Receptor Effect

Though inhibited by a drug, a cancer-promoting cell receptor may stage a comeback, becoming part of a receptor-receptor pair that signals cancer cells to proliferate, should growth factors be present. This undesirable teamwork, which was uncovered by scientists at the Francis Crick Institute, may explain why lapatinib failed clinical trials as a standalone drug against breast cancer.The scientists suggest that the drug-induced receptor-receptor effect they’ve found may do more than just un