TB Vaccine Induces Innate Response via Bone Marrow Stem Cells

Tuberculosis (TB) vaccines, including the well-known Bacillus Calmette–Guérin (BCG) vaccine, have focused on stimulating the adaptive immune system. Unfortunately, attempts to rouse the adaptive immune system against TB have yielded uneven results. The existing BCG vaccine is only partially effective, and vaccines in development keep racking up disappointments in preclinical and clinical trials. Now, with TB looking ever more dangerous as it evolves resistance to current antibiotics