Tau Tangles Cleared by Senolytic Drugs in Alzheimer’s Mice

Tangles of tau protein in the brain constitute a hallmark of Alzheimer’s disease, but exactly how these tangles exert their toxic effects remains poorly understood. In hopes of untangling tau’s mysteries, scientists based at the UT Health San Antonio delved into postmortem brain tissue from Alzheimer’s patients and generated transcriptomic profiles. These profiles revealed expression profiles consistent with cellular senescence, a kind of stressed state that allows cells to sur