Soluble Antibodies Promote Tumor Progression by Inducing Immune Suppressive Cells

Scientists at Wistar have found that soluble antibodies promote tumor progression by inducing accumulation of myeloid-derived suppressor cells (MDSCs) in pre-clinical cancer models. Their study (“ Secretory IgM exacerbates tumor progression by inducing accumulations of MDSCs in mice ”) appears in  Cancer Immunology Research .“Chronic lymphocytic leukemia cells can secrete immunoglobulin M. However, it is not clear whether secretory IgM (sIgM) plays a role in dise