Sex Determination for Males Hinges on Gene Enhancer

An international team of researchers says they have identified a key enhancer of Sox9 , a gene critical for male sex development, and demonstrated that deleting that noncoding DNA results in male-to-female sex reversal in mice. The study ( “Sex Reversal following Deletion of a Single Distal Enhancer of Sox9 ”)  published in  Science , deepens understanding of the normal process of sex determination in mammals and could also have important implications for patients