Sanofi to Develop Principia MS Candidate PRN2246 in Up-to-$805M Collaboration

Sanofi will develop Principia Biopharma’s Phase I central nervous system (CNS) candidate PRN2246 as a treatment for multiple sclerosis (MS), through a collaboration that could generate up to $805 million for Principia, the companies said today.PRN2246 is a low-dose, covalent Bruton's tyrosine kinase (BTK) inhibitor that can cross the blood–brain barrier to access the brain and spinal cord, enabling the drug to penetrate the CNS with the goal of effectively and safely modulating B-cel