RNA-Based Gene Therapy Can Be Turned ON or OFF via Synbio Switches

DNA-based gene therapy, the usual kind of gene therapy, is hard to deliver compared to RNA-based gene therapy. New DNA must enter the nucleus after being transported by nanoparticles or viral vectors, which can be inefficient or immunogenic. But once new DNA is in place, it has the advantage of being controllable. Gene expression may be turned up or down by any of several well-established methods. This kind of control has been lacking for RNA-based gene therapy, even though RNA promises safer, e