Proteomics Finding May Lead to Therapy Targeted at Cellular Pathway Linked to ALS

Scientists say they have described for the first time atom-by-atom changes in a protein family linked to amyotrophic lateral sclerosis (ALS). Their study (“ Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation ”) is published in Molecular Cell. “hnRNPA2, a component of RNA-processing membraneless organelles, forms inclusions when mutated in a syndrome characterized by the degenerat