Protein Regulator of Glioblastoma Migration Identified

Scientists at the Icahn School of Medicine at Mount Sinai have identified a protein called TEAD1 that appears to regulate the migration of human glioblastoma cells away from the primary brain tumor mass, into other areas of the brain. Their studies, reported in Nature Communications , found that knocking out the TEAD1 gene in patient-derived glioblastoma multiforme (GBM) cells grown in vitro  and transplanted into mice inhibited the cancer cells’ ability to proliferate and reduced the