Protein Binding Takes a Walk on the Unstructured Side

Proteins that bind with each other typically stick to the straight and narrow: well defined and highly structured binding sites. This convention is usually respected even by unstructured proteins, which commonly interact with well-structured binding sites on other molecules. Now, however, another kind of protein interaction has been observed, one that may transform our view of protein binding.Two intrinsically disordered proteins have been found to form a high-affinity complex that is itself uns