Prion Disease Harms Neurons via Stress Pathway

Prions beget prions, we know, but we lack a good understanding of prion diseases. We can follow the progress of prion diseases up to a certain point—the accumulation of misfolded proteins. To press forward, we need to see exactly how prions cause neuronal degeneration, the proximate cause of the symptoms associated with prion disorders, symptoms such as rapidly progressive dementia, seizures, and personality changes.In humans, prion disorders include Creutzfeldt-Jakob disease and kuru; in