Primary Breast Tumors Put the Brakes on Metastases

The spread of breast cancer to tissues and organs distant from the original tumor site is associated with poorer patient prognosis, and anticancer therapies are generally far less effective against metastatic disease. However, the mechanisms controlling metastasis aren’t well understood. Scientists in the U.S. and Australia have now discovered that the primary tumor can influence whether metastasis-initiating cells (MICs) that break away from the primary tumor site will be able to colonize