Phosphatases in Line for Target-Based Discovery

When drug developers assemble their Most Wanted lists, they may overlook the phosphatases, signaling enzymes that are notoriously hard to pick out of a lineup. Phosphatases, however, may soon find themselves the subject of intense investigation, now that scientists from the Medical Research Council (MRC) have created a platform for target-based discovery of phosphatase inhibitors.Unlike kinases, which come from a different family of signaling enzymes, phosphatases often lack distinguishing chara