Personalized Dendritic Cell Vaccines Could Improve Cancer Immunotherapy

Dendritic cell vaccines, a promising cancer immunotherapy approach, usually come from dendritic cells that have been force-fed with tumor antigens. Dendritic cells, however, can also be modified so that they gorge themselves on antigen-carrying exosomes released by tumor cells. Even better, modified dendritic cells aren’t finicky. Although ordinary dendritic cells usually consume antigens from lab-grown cancer cells, modified dendritic cells may feast on antigen-carrying exosomes from a pa