Obesity Tilts Breast Cancer Cells toward Metastasis by Suppressing Metabolic Enzyme

Obesity can promote the spread of breast cancer by inhibiting a metabolic enzyme, acetyl-coenzyme A-carboxylase 1 (ACC1), a central component of fatty acid synthesis. The inhibition of ACC1, report scientists based at Helmholtz Zentrum München, triggers a series of molecular events that culminates in the induction of metastasis.The scientists also say that blocking this inhibition, via a receptor-blocking antibody, reduced the spread of breast cancer in an experimental model. Such intervent