Obesity Factors Implicated in Anti-VEGF Therapy Failure against Breast Cancer

Obesity has been associated with reduced survival in some cancers. A new study headed by scientists at Massachusetts General Hospital (MGH) has now found that obesity may also explain why angiogenesis inhibitor therapy is ineffective against breast cancer (BC). The MGH research, including data from human breast cancer patients and experiments in two mouse models of the disease, suggest that obesity is associated with increased production of inflammatory and angiogenic factors that sustain angiog