O Radiotherapy Resistance, Where Is Thy STING?

Radiation therapy induces good inflammation and bad inflammation. The good inflammation boosts the activation of killer T cells and helps shrink tumors . The bad inflammation causes an influx of suppressive immune cells and gives rise to radiation resistance. These opposed tendencies, which may tip radiotherapy outcomes one way or another, are even more finely balanced than one might suppose. Both are influenced by the same signaling mechanism: the stimulator of interferon genes, or STING.The go