Novel Antibiotic Production Platform Harnesses Synthetic Biology and Chemistry

Researchers from the University of Bristol say they have combined synthetic biology and chemistry to create a modern technology platform to allow the production of novel antibiotics to combat increasing microbial drug resistance.The team is working on derivatives of pleuromutilin, with the core pleuromutilin isolated from the mushroom Clitopilus passeckerianus . Pleuromutilin derivatives are potent antibacterial drugs but often require difficult chemical modifications, according to the scientist