Newly Uncovered Pathway Points to New Strategies Against Ovarian Cancer

Scientists in the U.S. have uncovered a previously unknown molecular pathway in ovarian cancer that could lead to new therapeutic strategies that target a cancer-promoting mutant form of the tumor suppressor protein p53, known as p53-R175H.  The team at Baylor College of Medicine and the University of Texas MD Anderson Cancer Center has shown that inhibiting a deubiquitinase (DUB) known as USP15 allows the clump-forming mutant p53 to be tagged for degradation, which leads to increased cance