New Work Opens Door to Manipulating Aberrant Calcium Signaling in Immune System

Scientists at the La Jolla Institute for Immunology (LJI) have reported additional work on  how calcium-sensing protein STIM1 signals that it's time to initiate calcium retrieval and then relays that message to the calcium channel ORAI. This research, says the team, lays the groundwork for novel ways to manipulate aberrant calcium signaling in the immune system, particularly in the context of autoimmune or inflammatory disease. We've known for a decade that STIM1 protein move