Mitochondrial Protein Alterations May Underlie Inflammatory Myopathies

Scientists at the Institute for Research in Biomedicine (IRB), in Barcelona, report that the removal of a single mitochondrial protein in mouse muscle leads to severe inflammation throughout the body, causing the premature death of the animal. Their study (“ Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency ”) appears in The EMBO Journal .“Opa1 participates in inner mitochondrial membrane fusion and cristae morphogenesis. Here, we show that muscle-s