Mitochondrial DNA Varies between Mitochondria within Individual Cells

To find better ways of diagnosing and treating mitochondrial diseases, scientists sift through mitochondrial DNA—and they have just started to use a very fine screen. At the University of Pennsylvania School of Medicine, researchers led by James Eberwine, Ph.D., have developed a means of sequencing the DNA of individual mitochondria. The researchers have used this method, single-mitochondrion sequencing, to detect previously indiscernible—and likely meaningful—variability in mi