Membrane-Disrupting Components of Toxic Parkinson's Disease Elements Revealed

Collaborating scientists in the U.K., Spain and Italy have uncovered how the toxic clusters of protein molecules that cause Parkinson’s diseases latch onto the membranes of brain cells and disrupt integrity the lipid bilayer, causing cellular dysfunction that leads to cell death.Using techniques including solid state nuclear magnetic resonance spectroscopy (ssNMR), the researchers, led by professor Christopher Dobson, at the University of Cambridge, and Dr. Alfonso De Simone, from Imperial