Membralin Protein Found Critical in Regulating Amyloid-Beta Production

Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) say they have shown that membralin is critical for keeping Alzheimer's disease pathology in check. The study (“ ER-Associated Degradation Regulates Alzheimer’s Amyloid Pathology and Memory Function by Modulating γ-Secretase Activity ”), published in  Nature Communications , demonstrates that membralin regulates the cell's machinery for producing amyloid-beta (Aβ), the protein that c