Long ncRNA Must Linger to Enhance Gene Expression

Whether it dangles from chromatin or freely wanders the nucleoplasm, long noncoding RNA (ncRNA) does little to influence gene expression. But just after it is released—when it is free of chromatin but still close to its genetic target—long ncRNA can recruit transcription factors before it diffuses away and loses the name of action.These mechanistic details emerged from a study of long ncRNA conducted by a Danish-German team of scientists. The team may even have had Shakespeare’