Local Immunotherapy Shrinks Tumors Near and Far

Inject locally, treat globally. That’s the gist of a new cancer immunotherapy strategy called in situ vaccination. It has three steps: (1) Deliver immunoenhancing agents to a tumor site. (2) Trigger an immune response among “prescreened” T cells, that is, T cells that have already shown that they can infiltrate the tumor. (3) Watch the T cells attack cancer throughout the body. In situ vaccination was developed by Stanford University scientists who believe that their approach,