Liver Link between Obesity and Diabetes Highlights New Therapeutic Target

The strong links between obesity and the development of type 2 diabetes mellitus (T2DM) have long been recognized, but the cellular and molecular mechanisms underpinning that relationship are not yet well understood. An international team of scientists has now found that overexpression of the protein tyrosine phosphatase receptor gamma (PTPR-γ) specifically in the liver acts as the molecular link between obesity-induced inflammation and insulin resistance and could represent a new target f